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Continued use of cyclophosphamide is contraindicated in patients with severely depressed bone marrow functionCyclophosphamide is contraindicated in patients who have demonstrated a previous hypersensitivity to itSee WARNINGS and PRECAUTIONS
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Amenorrhea associated with decreased estrogen and increased gonadotropin secretion develops in a significant proportion of women treated with cyclophosphamideAffected patients generally resume regular menses within a few months after cessation of therapyGirls treated with cyclophosphamide during prepubescence generally develop secondary sexual characteristics normally and have regular mensesOvarian fibrosis with apparently complete loss of germ cells after prolonged cyclophosphamide treatment in late prepubescence has been reportedGirls treated with cyclophosphamide during prepubescence subsequently have conceived.
Special attention to the possible development of toxicity should be exercised in patients being treated with cyclophosphamide if any of the following conditions are present.
This medication may rarely cause very serious effects on the heartespecially when used in high dosesor in combination with radiation treatment or certain other chemotherapy drugse.gdoxorubicinSeek immediate medical attention if you developchest painjaw/left arm paintrouble breathingirregular heartbeatsymptoms of heart failuresuch as shortness of breathswelling ankles/feetunusual tirednessunusual/sudden weight gain
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