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The most severe complication of fmf is secondary amyloidosis; 9 however, it is less common in the colchicine and anti-il 1 era.
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Colchicine is not a pain medication and should not be used to relieve other causes of pain.
Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic dosesespecially in order plavix medication combination with other drugs known to cause this effectPatients with impaired renal function and elderly patientseven those with normal renal and hepatic functionare at increased riskOnce colchicine treatment is ceasedthe symptoms generally resolve within 1 week to several months.
No dedicated pharmacokinetic study using colchicine capsules has been conducted in patients with varying degrees of hepatic impairmentColchicine is known to be metabolized in humans and the presence of severe hepatic impairment has been associated with colchicine toxicityHepatic clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment.
Fatal overdosesboth accidental and intentionalhave been reported in adults and children who have ingested colchicineSee OVERDOSEColchicine capsules should be kept out of the reach of children.
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