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Although pfizer has continued to supply ponstel and its raw material to us under the same terms, we believe that pfizer will fulfill its obligations under the agreement to supply designated quantities of ponstel at or about the end of the first quarter of 2003.
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This medicine can also increase your risk of serious effects on the stomach or intestinesincluding bleeding or perforationforming of a holeThese conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking mefenamic acidOlder adults may have an even greater risk of these serious gastrointestinal side effects.
This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyAvoid alcoholic beveragesTalk to your doctor if you are using marijuana.
Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascularCVthrombotic eventsincluding myocardial infarctionMIand strokewhich can be fatalBased on available datait is unclear that the risk for CV thrombotic events is similar buy ceftin without prescription for all NSAIDsThe relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV diseaseHoweverpatients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic eventsdue to their increased baseline rateSome observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatmentThe increase in CV thrombotic risk has been observed most consistently at higher doses.
NSAIDsincluding mefenamic acidcan cause serious skin adverse reactions such as exfoliative dermatitisStevens-Johnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactions and to discontinue the use of Ponstel at the first appearance of skin rash or any other sign of hypersensitivityPonstel is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS
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