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In a cross-study population pharmacokinetic analysis, sinemet retard had comparable bioavailability to the oral immediate-release carbidopa-levodopa 25 100 mg tablets over-encapsulated tablets .

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The early diagnosis of this condition is important for the appropriate management of these patientsConsidering NMS as a possible diagnosis and ruling out other acute illnessese.gpneumoniasystemic infectionetcis essentialThis may be especially complex if the clinical presentation includes both serious medical illness and untreated or inadequately treated extrapyramidal signs and symptomsEPSOther important considerations in the differential diagnosis include central anticholinergic toxicityheat strokedrug feverand primary central nervous systemCNSpathology.

Swelling of the facelipsmouththroat or tongue which may cause difficulty in swallowing or breathing bleeding from the back passageblack sticky bowel motionsstoolsor bloody diarrhoea vomiting blood or material that looks like coffee grounds chest pain fast or irregular heartbeatsalso called palpitations muscle stiffness accompanied by fever mental changes such as feeling very fearful or paranoidhallucinations shortness of breathdifficulty breathing.

Levodopa has been detected in human milkCaution should be exercised when SINEMET is administered to a nursing woman.

Caution should be exercised when the following drugs are administered concomitantly with SINEMET.

All patients should be observed carefully for the development of depression with concomitant suicidal tendencies.

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